The Weirdest And Rarest Diseases Known To Mankind

There are an unfortunate number of people currently living around the world who are experiencing some of the rarest, weirdest diseases known to man.
Some of these are probably unheard of by many of you, but they do exist, and they are affecting the daily lives of those who are unlucky enough to have come down with the symptoms. There are treatments in some cases, but not all are so lucky. In fact, the majority have no known treatment and they still baffle doctors everywhere.

Exploding Head Syndrome

Exploding Head Syndrome sounds like something out of a bad horror movie, but it’s actually a serious disease affecting thousands around the world. Symptoms of the disease are what sounds like a bomb exploding, a gun firing off, a clash of cymbals, or another form of loud noise within one’s head while trying to sleep. There are no symptoms of pain, swelling or any other physical aspect, however. Individuals over 50 tend to be the most common recipients, but people as young as 10 have reported occurrences, too.

Alice in Wonderland Syndrome

Alice in Wonderland Syndrome sounds like something that was completely made up, but it isn’t, though it is named after the novel by Lewis Carroll. Symptoms include hallucinations, disorientation, dysmetropsia, or size distortion. Symptoms are common within childhood, but most grow out of it within their teens. Symptoms are not harmful and will disappear in time.

Alien Hand Syndrome

Alien Hand Syndrome is an incredibly rare neurological disease that causes random hand movements without the individual knowing what is happening or having any control. The person can reach for objects and manipulate them without them knowing about it. Unfortunately, there is no known cure for Alien Hand Syndrome. Symptoms can be reduced and managed, however. Holding an object within the affected hand can help a great deal.

Cotard’s Delusion

Cotard’s Delusion is a rare mental disease, where the person affected believes themselves to be completely dead. Some people afflicted, however, believe themselves to be completely immortal. Schizophrenia is quite common in many patients too. Treatment generally involves pharmacological drugs. Hemodialysis tends to resolve all symptoms.


Polydactylism, or the disease where extra fingers or toes are present on the body, is considered to be one of the more common diseases within the development of birth. One out of every 500 children have Polydactylism. The extra finger or toe tends to be nothing more than soft tissue with no bone. Surgery to remove the extra digit is the only option.


Argyria is a disease caused by too much exposure to chemical compounds of silver. The worst symptom of the disease is the skin turning blue or a bluish-grey. Large areas of the body are affected by the disease, though some areas can be localized, such as in patches of skin. A laser is said to help for silver ingestion, though some have died from the disease.

Werewolf Syndrome

Werewolf Syndrome, most commonly known as Hypertrichosis, is known for the growth of hair over the majority of the body. There are two known types, including generalized, covering the entire body, and localized, which covers a very specific area. There is no cure, however, but you can manage the symptoms in patients. Temporary hair removal can last from several hours to several weeks.

Lamprey Disease

Lamprey Disease was one of the most terrifying diseases said to be spreading among the human population. However, it was later revealed to be an email hoax that preyed on those who would be particularly grossed out by the idea of a body part being replaced by the mouth of a Lamprey. It was said to feature a “toothed, funnel-like sucking mouth” on various body parts, such as in the eye. Thank goodness for this one being called out.
The Weirdest And Rarest Diseases Known To Mankind The Weirdest And Rarest Diseases Known To Mankind Reviewed by 1 on April 15, 2018 Rating: 5
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